AstraZeneca R&D Gothenburg, Sweden
Keywords of expertise: 1. PBPK modeling, 2. Pulmonary drug delivery, 3. Pharmacokinetics, 4. Drug product development
Golden Paragraph: Helena Thörn works at AstraZeneca R&D in Gothenburg, Sweden and holds a position as a Senior Scientist in Biopharmaceutics with main focus in the inhaled drug delivery area. She has a Master of Science in Pharmacy and a PhD in Biopharmaceutics from Uppsala University. Her research has been focused on mechanistic understanding of drug absorption and the fate of an active moiety from administration to its site of action. She is experienced in PBPK modeling and believe that this tool will help to improve the understanding of the multiple factors involved in the absorption of an inhaled drug. The model need to take into account the deposition of the drug in the airways as well as the following mucociliary clearance, dissolution, permeation, tissue binding and the systemic distribution of the drug. A well-developed PBPK model together with high quality input data has the potential to predict the lung tissue concentration, i.e. concentration at target site. In the SimInhale collaboration Helena can provide expertise in the multiple factors involved in pulmonary drug absorption and insight into how the human physiology in combination with device, inhalation maneuver, drug characteristics and formulation factors will determine the lung tissue and plasma concentration.