Martin-Luther-University Halle-Wittenberg, Germany
Keywords of expertise: 1. Computational Fluid Dynamics, 2. Lattice-Boltzmann Method, 3. Dry Powder Inhaler, 4. Drug Detachment Models
Golden Paragraph: Yan Cui holds an Assistant Researcher position in the Department of Mechanical Process Engineering at the Martin-Luther-University Halle-Wittenberg in Germany. The primary research activity of Yan in SimInhale is to study the detachment of micro-sized fine drug particles from a larger carrier particle under various flow conditions by using the Lattice Boltzmann Method. This study is used for predicting the drug delivery efficiency inside the Dry Powder Inhaler. In this regard, three detachment models, i.e. plane wall detachment model, rough wall detachment model and cluster-wall collision model, were developed based on measured contact properties for different flow conditions and cluster structures. Moreover, those detachment models are implemented into the OpenFOAM® and are used for Euler/Lagrange calculations of an inhaler device and allow an optimization with regard to pressure drop and efficiency of drug powder delivery. Finally, he is looking for collaboration with other SimInhale members who can provide measured particle contact properties (e.g. adhesion force, surface energy, friction coefficient) for different surface treatment methods of carrier particles.