SimInhale COST Action MP1404, Training School, Belgrade 27-28 February 2018
WG1 and WG2 Workshop
“Particle Engineering and Device Development for Pulmonary Drug Delivery: What is new?”
- Workshop overview and objectives
- This was an intensive two-day workshop focused on the new developments in the device and formulation development in pulmonary drug delivery. The workshop featured an interesting mix of pioneering researchers and experts from industry and academia.
- In the workshop following topics were discussed:
- Innovative particle engineering and formulation technologies
- Lung delivery of biological molecules such as siRNA
- Advances in device development
- Novel devices for the delivery of small and large molecular drugs including antibiotics drugs
- Integrated device and formulation development
- The participants received an update on the recent developments in the formulation technologies and various inhalation devices (pMDIs, DPIs, soft mist inhalers, nebulisers) for orally inhaled drug products. In particular, the importance and challenges involved in integrated device and formulation development were discussed.
- Workshop info and agenda (Updated 19 January 2018)
SimInhale COST Action MP1404, Training School, Athens 2-4 October 2017
“The emerging role of fluid-particle dynamics and reduced methods in the context of in silico population studies for pulmonary drug development”
- The participants were introduced to the state of the art in pulmonary drug delivery with particular attention to the science, technology and regulation of orally inhaled drug products. Through the course, the participants gained a spherical view of the current state of pulmonary drug delivery, allowing them to form a clear picture of where in silico methods fit in this highly multidisciplinary field.
- Through the course the following aspects were addressed:
- Aerosol characterization
- Dissolution characterization
- In vitro aerosol measurements
- Estimates of lung dose via charcoal blocked AUC
- In vitro – in vivo correlations, 1D models and PK
- CFD methods: current state of the art and open questions
- Modeling the deep lung: models of deposition in the acinus
- Quantitative lung imaging for the assessment of lung structure and function
- Lab session: proving hands-on experience with cascade impactor measurements
- Quality by Design and industry perspectives
- The participants were introduced to the state of the art in pulmonary drug delivery with particular attention to the science, technology and regulation of orally inhaled drug products. Through the course, the participants gained a spherical view of the current state of pulmonary drug delivery, allowing them to form a clear picture of where in silico methods fit in this highly multidisciplinary field.
- Through the course the following aspects were addressed:
SimInhale COST Action MP1404, Training School, Malta 20-22 February 2017
WG1 and WG2 Workshop
“Emerging Device and Particle Engineering Technologies for Optimal Pulmonary Drug Delivery”
- Workshop overview and objectives
- This was an intensive three-day course focused on the device and particle engineering technologies for optimal pulmonary drug delivery. Trainers consisted of a good mix from academia and the industry.
- Through the course the following aspects were addressed:
- Lung biopharmaceutics and pharmacokinetics
- Particle engineering and formulation
- Device engineering
- Lung targeting and toxicity
- Regulatory aspects of inhaled products
- The participants were introduced to the state-of-the art in pulmonary drug delivery with particular attention to science, technology and regulation of orally inhaled drug products. During the course, the participants got an overview of different inhalation devices (pMDIs, DPIs, soft mist inhalers, nebulisers), formulation methods for DPIs, toxicity, lung targeting, pharmacokinetics, regulatory constraints for inhalation devices, usability aspects and adherence.
SimInhale COST Action MP1404, Training School, Prague 18-19 October 2016
WG3 and WG4 Workshop
“Pulmonary Drug Delivery: Computational Fluid Particle Dynamics and Emerging Functional Imaging Technologies”
- Workshop overview and objectives
- This was an intensive two-day workshop on the current state of the art on Pulmonary Drug Delivery from the perspective of Computational Fluid Particle Dynamics (CFPD) and Emerging Functional Imaging Technologies. The workshop featured an interesting mix of talks and features lecturers from the academic and research communities, the industry and the medical professions.
- Through the workshop the following aspects were tackled:
- State of the art in human airways model construction
- Biodistibution of inhaled agents in health and disease
- Inhaler devices design and optimization issues
- Quantifying regional deposition via CFPD and lung imaging
- Workshop participants can participate in the CFPD computation of a selected benchmark case. Results and comparison were presented at the workshop.
- Workshop info and agenda (Updated 22 September 2016)